![]() ![]() ![]() The main limitation of CEUS is the practice mode, because the interpretation of ultrasound images depends on technical skills and the experience of the radiologist. It improves the accuracy of ultrasound for diagnosis of superficial lymph nodes disorders. Ĭompared with CT and MRI, gray-scale ultrasound combined with CEUS can assess the shape, margins, internal structure, and vascularization of superficial lymph nodes. Previous studies have shown that CEUS has a higher sensitivity in identifying small blood vessel reductions or areas of multiple blood vessels that cannot be detected by Doppler technology leading to a better evaluation of LNS classification. Recently, CEUS has often been used to identify benign and malignant superficial lymph nodes. Its contrast pool, sensitivity and specificity in diagnosing liver lesions are similar to contrast CT on the contrary CT is more costly and involves higher levels of ionizing radiation exposure. ĬEUS helps radiologists investigate and characterize focal lesions. It has been widely performed in identification of sentinel lymph node in breast cancer patients. It has been widely used to evaluate liver, kidney, pancreas, spleen, ovarian, thyroid, breast, prostate and even lung lesions in the current clinical practice. Ĭontrast-enhanced ultrasound (CEUS) is a new technique used for real-time assessment of tissue perfusion. And previous studies reported that NUS and FNA of cervical lymph nodes is a potential modality that can be used for the diagnosis of sarcoidosis patients. 10.8% of patients with sarcoidosis are reported to have enlarged cervical lymphadenopathy on ultrasound. Īlthough great efforts have been devoted to establish methodologies that can differentiate sarcoidosis from other lung diseases, the diagnosis of sarcoidosis still requires histological confirmation to detect the presence of granulomatous inflammation and also to exclude other potential causes of granulomatous inflammation simultaneously. China has a high prevalence of TB, which causes a significant challenge in differentiating sarcoidosis from other granulomatous lung diseases especially in cases of smear-negative for tuberculosis. The confirmatory diagnosis of sarcoidosis is established only when clinic-radiographic findings are supported by histological evidence of non-caseating granulomatous inflammation with other causes of granulomas and local reactions have been reasonably excluded. Sarcoidosis is a diagnosis of exclusion because of its similarity in the clinical presentations to other lung diseases (such as tuberculosis, fungal infections, lung cancer, and cryptogenic organizing pneumonia). In addition to the lung and intrathoracic lymph nodes, many organs including cervical lymph node could be involved. ![]() Sarcoidosis is a systemic disease of unknown etiology, with the pathological feature of non-caseous epithelioid granulomas. The binary classification model of NUS combined with CEUS features can help differentiate sarcoidosis from non-sarcoidosis groups. NUS combined with CEUS has characteristic features in sarcoidosis with cervical lymph node involvement, which is helpful for its diagnosis and differential diagnosis. The percentage correction of prediction was 90% (18/20). Similarly, we also acknowledged a statistically significant differences in EM, homogeneity, presence or absence of necrosis between the sarcoidosis and non-sarcoidosis groups via CEUS to further group the non-sarcoidosis into tuberculosis, malignancy or inflammatory disorder. There were statistically significant differences in symmetry, lymphatic hilum, homogeneity, CDFI pattern and elasticity score between the sarcoidosis and non-sarcoidosis groups via NUS. Of 88 patients included in this study, sarcoidosis was accounted in 20 cases, tuberculosis in 23 cases, malignancy in 22 cases and inflammatory lymph node in 23 cases. Seven characteristics such as enhanced mode (EM), resolution time, color Doppler flow imaging (CDFI), fading time, peaking state-uniformity, strengthen the area and symmetry were considered to perform the logistic regression model. MethodsĨ8 patients with evidence of intrathoracic lymphadenopathy and suspected sarcoidosis with enlarged cervical lymph nodes underwent NUS, CEUS, fine-needle aspiration and core needle biopsy when technically feasible were retrospectively analyzed in this study. To explore the significance of neck ultrasound (NUS) combined with contrast-enhanced ultrasound (CEUS) in the diagnosis of sarcoidosis. ![]()
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